Inflammatory Myofibroblastic Tumors of the Female Genital Tract Are Under-recognized

Inflammatory Myofibroblastic Tumors of the Female Genital Tract Are Under-recognized

Inflammatory myofibroblastic tumor (IMT) of the female genital tract is under-recognized. We investigated the prevalence of ALK-positive IMT in lesions previously diagnosed as gynecologic smooth muscle tumors. Immunohistochemistry (IHC) for ALK was performed on tissue microarrays of unselected tumors resected from 2009 to 2013. Three of 1176 (0.26%) "leiomyomas" and 1 of 44 (2.3%) "leiomyosarco...

Female Genital Tract Tumors

Smooth Muscle Tumors of the Female Genital Tract.

Smooth muscle tumors are the most common among mesenchymal tumors in the female genital tract. The vast majority of these neoplasms are clinically benign and easy to diagnose. In contrast, leiomyosarcomas are highly aggressive tumors that may pose considerable diagnostic problems when they display unusual (myxoid or epithelioid) morphology, ambiguous histologic features for malignancy, or an un...

Mesenteric inflammatory myofibroblastic tumors

Inflammatory myofibroblastic tumors (IMTs), also known as inflammatory pseudotumors and inflammatory fibrosarcomas, are uncommon mesenchymal tumors composed of myofibroblastic spindle cells admixed with lymphocytes, plasma cells and eosinophils. Once thought to be reactive, these lesions are now considered to be neoplastic. These tumors can occur throughout the body, most commonly in the lung, ...

Immunohistochemistry of Inflammatory myofibroblastic tumors

Background: Inflammatory myofibroblastic tumor (IMT) or inflammatory pseudotumor is a tumoral lesion which can be seen in all age groups and in all internal organs. It is in differential diagnosis with some important neoplasms such as Leiomyosarcoma, Rhabdomyosarcoma, and Sarcomatoid carcinoma. Differentiation between these tumors requires a special diagnostic tool such as Immunohistochemistry ...